تفاعل #40710

معادلة التفاعل

4-morpholinoacetophenone

N,N-dimethylformamide dimethyl acetal

hydrazine hydrate

→

title compound

4-[4-(1H-Pyrazol-3-yl)phenyl]morpholine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 7 hours
3. 3
   درجة الحرارةagain heated
4. 4
   درجة الحرارةunder reflux for about 6 hours
5. 5
   أخرىThe solid formed
6. 6
   درجة الحرارةon cooling the mixture
7. 7
   ترشيحwas filtered off with suction
8. 8
   غسيلthoroughly washed with methanol

الإجراء التجريبي

A mixture of 2.05 g of 4-morpholinoacetophenone (10 mmol) and N,N-dimethylformamide dimethyl acetal was heated under reflux for 7 hours. The mixture was then mixed with 30 ml of methanol and, after addition of 0.57 ml of hydrazine hydrate, again heated under reflux for about 6 hours. The solid formed on cooling the mixture was filtered off with suction and thoroughly washed with methanol, resulting in 3.8 g of the title compound.

المصدر