تفاعل #4070

معادلة التفاعل

methyl bromo-phenylacetate

methyl ammonium chloride

sodium bicarbonate

water

→

title compound

المردود 71.2%

Methyl Methyamino-phenylacetate

المردود 71.2%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto refluxed
2. 2
   درجة الحرارةrefluxed for about 18 hours
3. 3
   درجة الحرارةThe mixture was then cooled
4. 4
   غسيلwashed three times with water
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   تركيزconcentrated by vacuum evaporation

الإجراء التجريبي

In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.

المصدر