تفاعل #40698

معادلة التفاعل

sodium hydrogen carbonate

compound

benzyl (3S)-2-oxotetrahydro-3-furanylcarbamate

sulfuric acid

→

title compound

methyl(2S)-2-{[(benzyloxy)carbonyl]amino}-4-hydroxybutanoate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 2 hrs
2. 2
   ترشيحAfter celite filtration of the reaction mixture
3. 3
   أخرىthe solvent was evaporated

الإجراء التجريبي

To the compound (500 mg) obtained in Step 1 were added methanol (5 ml) and conc. sulfuric acid (30 μl), and the mixture was stirred overnight at 60° C. To the reaction mixture was further added sodium hydrogen carbonate (250 mg), and the mixture was stirred at room temperature for 2 hrs. After celite filtration of the reaction mixture, the solvent was evaporated to give the title compound as a crude product.

المصدر