تفاعل #40697

معادلة التفاعل

benzyl chloroformate

L-homoserine

sodium hydrogen carbonate

water

→

title compound

benzyl (3S)-2-oxotetrahydro-3-furanylcarbamate

المذيبات

ether

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 18 hrs
2. 2
   غسيلwashed with 1N hydrochloric acid
3. 3
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
4. 4
   أخرىthe solvent was evaporated
5. 5
   أخرىThe obtained crude product
6. 6
   أخرىwas purified by silica gel chromatography (ethyl acetate-hexane)

الإجراء التجريبي

To L-homoserine (2 g) were added sodium hydrogen carbonate (3.7 g) and water (30 ml), and the mixture was stirred at room temperature for 1 hr. To the reaction mixture were further added benzyl chloroformate (3.9 ml) and ether (10 ml), and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was diluted with ethyl acetate and washed with 1N hydrochloric acid. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated. The obtained crude product was purified by silica gel chromatography (ethyl acetate-hexane) to give the title compound (2.5 g).

المصدر