تفاعل #40662

معادلة التفاعل

1d

2-(4,4-Dimethyl-3,4-dihydro-2H-quinolin-1-yl)-phenylamine

benzoyl isothiocyanate

→

1-benzoyl-3-(2-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)phenyl)thiourea

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   أخرىthe solvent was evaporated
3. 3
   تجفيفThe resulting crude 1e was dried over vacuum

الإجراء التجريبي

1d (65.4 mg, mmol) and benzoyl isothiocyanate (60 mg) were heated at refluxing CH2Cl2 for 2 h. After cooling, the solvent was evaporated. The resulting crude 1e was dried over vacuum and used directly in the next step: LC-MS ESI, 416.3 (M+H) (10-90% MeOH in H2O with 0.1% TFA in a 4 min run, tR=4.49 min).

المصدر