تفاعل #40576

معادلة التفاعل

4-Chlorophenylacetic acid

hydrogen chloride methanol

→

methyl 2-(4-chlorophenyl)acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated under reflex for 14 hours
2. 2
   أخرىThe solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   استخلاصfollowed by extraction with ethyl acetate
5. 5
   تجفيفThe organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure

الإجراء التجريبي

4-Chlorophenylacetic acid (5.0 g) was dissolved in 10% hydrogen chloride-methanol solution (50 ml) and heated under reflex for 14 hours. The solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure to provide methyl 2-(4-chlorophenyl)acetate (5.35 g) as a colorless, oily substance.

المصدر