تفاعل #40560

معادلة التفاعل

6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

ortho-phenylenediamine

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

→

6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added
2. 2
   workup.DISTILLATIONFor workup, the solvent is distilled off
3. 3
   أخرىis suspended in water at 70° C
4. 4
   ترشيحThe precipitate is filtered off
5. 5
   غسيلwashed several times with water
6. 6
   أخرىdried in vacuo

الإجراء التجريبي

30.5 g of 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid, 18 g of ortho-phenylenediamine and 2 g of DMAP are dissolved in 800 ml of DMF, at room temperature 32.2 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride are added, and the resulting solution is stirred at room temperature for 4 hours. For workup, the solvent is distilled off and the residue is suspended in water at 70° C. The precipitate is filtered off, washed several times with water and then dried in vacuo.

المصدر