تفاعل #40531

معادلة التفاعل

2-amino-3-nitro-benzoic acid methyl ester

bromine

→

title compound

المردود 87.4%

2-Amino-5-bromo-3-nitro-benzoic acid methyl ester

المردود 87.4%

المذيبات

acetic acid

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated yellow solid was collected by suction filtration
2. 2
   أخرىdried

الإجراء التجريبي

To a solution of 2.23 g (10.4 mmol) of 2-amino-3-nitro-benzoic acid methyl ester in 12 mL of acetic acid was added dropwise over 5 minutes a solution of 0.53 mL (10.4 mmol, 1 eq) of bromine in 2 mL of acetic acid. The mixture was stirred at room temperature for 30 minutes and poured into 100 grams of ice. The precipitated yellow solid was collected by suction filtration and dried to afford 2.50 g (82%) of the title compound as a yellow solid. 1H NMR (CDCl3) δ 3.95 (s, 3H), 8.35 (br s, 2H), 8.6 (d, 1H).

المصدر