تفاعل #40528

معادلة التفاعل

3,3-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Trifluoroacetic acid

trifluoroacetic acid

→

3,3-Dimethyl-piperidin-4-one

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe reaction stirred at room temperature 3 days
2. 2
   تركيزThe pale yellow solution was concentrated
3. 3
   أخرىto afford an oily residue, which
4. 4
   أخرىwas triturated with ether
5. 5
   ترشيحThe solids were collected by suction filtration
6. 6
   أخرىdried in vacuo

الإجراء التجريبي

The 3,3-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester thus prepared (450 mg, 1.97 mmol) was dissolved in methylene chloride (10 mL). Trifluoroacetic acid was added (305 uL) and the resulting solution stirred at room temperature 2 h. Additional trifluoroacetic acid was added (300 uL) and the reaction stirred at room temperature 3 days. The pale yellow solution was concentrated to afford an oily residue, which was triturated with ether. The solids were collected by suction filtration and dried in vacuo. 3,3-Dimethyl-piperidin-4-one was isolated and used as its trifluoroacetic acid salt (381 mg, 80%).

المصدر