تفاعل #40419

معادلة التفاعل

N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)-carbonylamino]-3-hydroxyphenyl}carboxamide

Cs2CO3

ethyl bromoacetate

→

crude compound

المردود 112.4%

ethyl 2-{3-[N-(5-chloro(2-pyridyl))carbamoyl]-4-[(4-cyanophenyl)carbonylamino]-phenoxy}acetate

المردود 112.4%

المذيبات

DMF

EtOAc

water

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic layer was washed with brine
2. 2
   أخرىdried
3. 3
   أخرىevaporated

الإجراء التجريبي

To a mixture of compound N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)-carbonylamino]-3-hydroxyphenyl}carboxamide (50 mg, 0.13 mmol) and Cs2CO3 (83 mg, 0.25 mmol) in DMF (1 mL) at room temperature was added ethyl bromoacetate (15 μL, 0.13 mmol). The mixture was stirred for 1 hour before diluted with EtOAc (20 mL) and water (10 mL). The organic layer was washed with brine dried and evaporated to give 70 mg of the crude compound, which was used without further purification. MS found for C24H19ClN4O3 (M+H)+: 479.0.

المصدر