تفاعل #40364

معادلة التفاعل

4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline

acetonitrile

N-(dimethoxymethyl)-N-methylethanamine

→

N′-{4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylimido-formamide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   درجة الحرارةThe reaction mixture was refluxed for 20 hrs
3. 3
   تركيزThe reaction mixture was concentrated in vacuo
4. 4
   workup.ADDITIONdiluted with ethyl acetate
5. 5
   غسيلwashed with water
6. 6
   تجفيفThe organic layer was dried over magnesium sulfate
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىyielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45

الإجراء التجريبي

To a mixture of 310 mg (0.8 mmol) of 4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline in 20 ml acetonitrile 208 mg (1.5 mmol) of N-(dimethoxymethyl)-N-methylethanamine (77% pure) was added. The reaction mixture was refluxed for 20 hrs. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate and concentrated in vacuo yielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45.

المصدر