تفاعل #4027

معادلة التفاعل

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was heated for 15 hours
2. 2
   درجة الحرارةunder reflux
3. 3
   استخلاصthe organic layer was extracted with chloroform
4. 4
   غسيلAfter washing the
5. 5
   استخلاصextract three times with water
6. 6
   أخرىthe chloroform was removed by distillation
7. 7
   أخرىThe residue was recrystallized from a mixture of acetone and hexane

الإجراء التجريبي

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

المصدر