تفاعل #40269

معادلة التفاعل

4-(4-Aminophenyl)butyric acid

methanol

hydrogen chloride

→

methyl 4-(4-aminophenyl)butyrate hydrogen chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىwas bubbled through the solution
2. 2
   درجة الحرارةAfter the reaction mixture was cooled to room temperature
3. 3
   workup.ADDITIONethyl ether (100 ml.) was added
4. 4
   أخرىThe mixture, which separated into two layers
5. 5
   ترشيحThe crystalline product was collected by filtration
6. 6
   أخرىdried thoroughly
7. 7
   أخرىThe filtrate was evaporated to dryness
8. 8
   أخرىthe residue was recrystallized from MeOH/benzene

الإجراء التجريبي

4-(4-Aminophenyl)butyric acid (5 g) was dissolved in 40 ml methanol. The solution was refluxed at 80-90° C. with stirring for 4 h while hydrogen chloride gas was bubbled through the solution. After the reaction mixture was cooled to room temperature, ethyl ether (100 ml.) was added. The mixture, which separated into two layers, was refrigerated overnight. The crystalline product was collected by filtration and dried thoroughly. The filtrate was evaporated to dryness and the residue was recrystallized from MeOH/benzene. The total amount of the product methyl 4-(4-aminophenyl)butyrate hydrogen chloride obtained was 5.6 g (87.5%), m.p. 143-145° C.

المصدر