تفاعل #4017

معادلة التفاعل

2-chloro-1,1,1-triethoxyethane

2-aminothiophenol

→

2-chloromethylbenzothiazole

المردود 91.3%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   غسيلthe resulting solution was washed with 3N HCl (10 ml)
2. 2
   أخرىThe organic portion was evaporated
3. 3
   أخرىthe residue chromatographed over silica gel

الإجراء التجريبي

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

المصدر