تفاعل #4009

معادلة التفاعل

2-amino-4-chloro-6-chloromethylpyrimidine

potassium t-butoxide

n-butanol

→

2-amino-4-n-butoxy-6-chloromethylpyrmidine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter this time, the solution was cooled
2. 2
   أخرىevaporated in vacuo
3. 3
   أخرىThe residue was partitioned between ethyl acetate and water
4. 4
   أخرىthe organic phase was separated
5. 5
   غسيلwashed three times with water
6. 6
   تجفيفthen dried (MgSO4)
7. 7
   أخرىEvaporation of the solvent
8. 8
   أخرىgave the crude product which
9. 9
   أخرىwas purified by chromatography on silica (Merck Kieselgel 60)
10. 10
    غسيلeluted with ether

الإجراء التجريبي

3,56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine and 2.24 parts of potassium t-butoxide were dissolved in 60 parts of n-butanol at room temperature then the solution was heated at 50° C. for 2 hours, with stirring. After this time, the solution was cooled and evaporated in vacuo. The residue was partitioned between ethyl acetate and water and the organic phase was separated and washed three times with water then dried (MgSO4). Evaporation of the solvent gave the crude product which was purified by chromatography on silica (Merck Kieselgel 60) eluted with ether to give 2-amino-4-n-butoxy-6-chloromethylpyrmidine as an oil.

المصدر