تفاعل #3985

معادلة التفاعل

4-Amino-1-(naphth-2-ylmethyl)piperidine

benzoylisothiocyanate

→

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   workup.DISSOLUTIONthe gum dissolved in isopropyl alcohol
3. 3
   أخرىThe solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
5. 5
   أخرىThe title compound crystallised
6. 6
   ترشيحwas filtered
7. 7
   تجفيفdried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

الإجراء التجريبي

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

المصدر