تفاعل #3981

معادلة التفاعل

Water

4-Benzoylureidopiperidine

2-(bromomethyl)naphthalene

triethylamine

→

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitated solid filtered off
2. 2
   غسيلwashed well with water
3. 3
   درجة الحرارةheated until all the solid
4. 4
   workup.DISSOLUTIONhad dissolved
5. 5
   أخرىThe title compound crystallised
6. 6
   أخرىwas collected as the hydrochloride salt, hemihydrate (1.6 g), m.p. 232°-234° C.

الإجراء التجريبي

4-Benzoylureidopiperidine (1.28 g, 0.005 m), 2-(bromomethyl)naphthalene (1.1 g, 0.005 m) and triethylamine (0.6 g, 0.006 m) in dimethylformamide (25 cm3) were stirred at room temperature for 23 hours. Water was added and the precipitated solid filtered off and washed well with water. The solid was suspended in warm ethanol, acidified with ethanolic HCl and then heated until all the solid had dissolved. The title compound crystallised and was collected as the hydrochloride salt, hemihydrate (1.6 g), m.p. 232°-234° C.

المصدر