تفاعل #3968

معادلة التفاعل

2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine

hydrazine hydrate

→

2-(2-Methoxy-4-amino-5-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 1.75 hours
2. 2
   تركيزThe reaction mixture is concentrated by evaporation
3. 3
   أخرىthe residue is triturated with 50 ml of ice water
4. 4
   أخرىthe product precipitated
5. 5
   أخرىis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)]

الإجراء التجريبي

One half gram of 2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine is suspended in 10 ml of isopropanol, mixed with 0.5 ml of 80% hydrazine hydrate, and refluxed for 1.75 hours with stirring. The reaction mixture is concentrated by evaporation, the residue is triturated with 50 ml of ice water, and the product precipitated is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)].

المصدر