تفاعل #3963

معادلة التفاعل

water

2-(2-dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one

hydrogen

hydrochloric acid

→

2-(2-Dimethylamino-4-amino-phenyl)-4H-imidazo[4,5-b]-pyridin-5-one hydrochloride

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture is filtered off from the catalyst
2. 2
   workup.ADDITIONthe mother liquor is mixed with 100 ml each of ether and of ethyl acetate, and finally 3 ml of etheral hydrochloric acid
3. 3
   workup.ADDITIONare added
4. 4
   أخرىThe precipitate is recrystallized from methanol
5. 5
   تجفيفAfter drying over phosphorus pentoxide and potassium hydroxide
6. 6
   أخرىa product is obtained which

الإجراء التجريبي

An amount of 1.7 gm of 2-(2-dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one is dissolved in 20 ml of dimethylformamide and mixed with 0.2 gm of 10% palladium/charcoal. The mixture is hydrogenated for three hours with hydrogen at ambient temperature under 5 bars of pressure. The mixture is filtered off from the catalyst, the mother liquor is mixed with 100 ml each of ether and of ethyl acetate, and finally 3 ml of etheral hydrochloric acid are added. The precipitate is recrystallized from methanol. After drying over phosphorus pentoxide and potassium hydroxide, a product is obtained which contains 1.5 mol of hydrochloric acid and 0.5 mol of water to 1 mol of base.

المصدر