تفاعل #3958

معادلة التفاعل

4-amino-5-(2-methoxy-4-methylmercapto-benzoylamino)-pyrimidin-2,6-dione

sodium hydroxide

→

crude product

8-(2-Methoxy-4-methylmercapto-phenyl)-purin-2,6-dione

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىa solution is formed
2. 2
   درجة الحرارةAfter cooling
3. 3
   ترشيحfiltered with glacial acetic acid
4. 4
   غسيلwashed with water
5. 5
   أخرىdried at 70° C. in a circulating air drier

الإجراء التجريبي

Two grams of 4-amino-5-(2-methoxy-4-methylmercapto-benzoylamino)-pyrimidin-2,6-dione are refluxed for 21 hours with 50 ml of ethanol and 50 ml of 2N sodium hydroxide solution. After about 15 minutes, a solution is formed. After cooling, the solution is suction filtered with glacial acetic acid, washed with water, and dried at 70° C. in a circulating air drier. The crude product thus obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (19:1, 9:1, 4:1 and ethanol)].

المصدر