تفاعل #3957

معادلة التفاعل

water

2-methoxy-4-methylmercapto-benzoic acid

4,5-diamino-pyrimidin-2,6-dione

→

4-Amino-5-(2-methoxy-4-methylmercapto-benzoylamino)-pyrimidin-2,6-dione

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture is refluxed for three hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   درجة الحرارةAfter cooling
4. 4
   أخرىThe product precipitated
5. 5
   ترشيحfiltered
6. 6
   غسيلwashed with water
7. 7
   أخرىdried at 70° C. in a circulating air drier

الإجراء التجريبي

Twenty grams of 2-methoxy-4-methylmercapto-benzoic acid is dissolved in 260 ml of dimethylformamide, mixed with 13 gm of N,N'-carbonyl-diimidazole, and stirred for 30 minutes at ambient temperature. Then, 13 gm of 4,5-diamino-pyrimidin-2,6-dione are added, and the reaction mixture is refluxed for three hours with stirring. After cooling, it is poured into 1 liter of water. The product precipitated is suction filtered, washed with water, and dried at 70° C. in a circulating air drier.

المصدر