تفاعل #3950

معادلة التفاعل

2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

hydrochloric acid

→

2-(2-Dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one

المذيبات

ظروف التفاعل

المعالجة

1. 1
   استخلاصneutralized, and extracted with ethyl acetate
2. 2
   غسيلAfter washing with water
3. 3
   تجفيفdrying with magnesium sulfate
4. 4
   أخرىthe ethyl acetate phase is evaporated
5. 5
   أخرىThe residue is crystallized by trituration in ether/petroleum ether

الإجراء التجريبي

A quantity of 0.2 gm of 2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine is heated in a bomb tube to 100° C. for three hours with 5 ml of concentrated hydrochloric acid. The reaction mixture is poured onto about 20 ml of ice, neutralized, and extracted with ethyl acetate. After washing with water and drying with magnesium sulfate, the ethyl acetate phase is evaporated. The residue is crystallized by trituration in ether/petroleum ether.

المصدر