تفاعل #3941

معادلة التفاعل

sodium hydroxide

thiourea

1-(4-chlorobenzyl)-4-(3-chloropropyl)homopiperazine

ethanol

→

3-[4-(4-chlorobenzyl)homopiperazin-1-yl]propanethiol

المردود 39.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed for 6 hours
2. 2
   درجة الحرارةthe resulting solution was refluxed for 4 hours
3. 3
   أخرىThe ethanol was removed in vacuo, and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   استخلاصThe product was extracted with methylene chloride
6. 6
   تجفيفthe extract was dried (sodium sulfate)
7. 7
   تركيزconcentrated

الإجراء التجريبي

4.1 g of thiourea were added to a mixture of 8.0 g of 1-(4-chlorobenzyl)-4-(3-chloropropyl)homopiperazine and 100 ml of reagent ethanol. The mixture was refluxed for 6 hours and then stirred overnight at room temperature. A solution of 5.0 g of sodium hydroxide in 30 ml of water was added, and the resulting solution was refluxed for 4 hours. The ethanol was removed in vacuo, and water was added to the residue. The product was extracted with methylene chloride, and the extract was dried (sodium sulfate) and concentrated to give 3.1 g (39% of theory) of 3-[4-(4-chlorobenzyl)homopiperazin-1-yl]propanethiol as a yellow oil.

المصدر