تفاعل #3928

معادلة التفاعل

1-(4-chlorobenzyl)piperazine

1-bromo-2-chloroethane

→

1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride

المردود 112.0%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 8 hours
2. 2
   أخرىThe solvent was removed in vacuo, and 2N sodium hydroxide
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   استخلاصThe product was extracted with methylene chloride
5. 5
   تجفيفthe extract was dried (sodium sulfate)
6. 6
   تركيزconcentrated
7. 7
   أخرىThe salt was precipitated with ethereal hydrochloric acid

الإجراء التجريبي

A mixture of 15.0 g of 1-(4-chlorobenzyl)piperazine, 14.4 g of 1-bromo-2-chloroethane and 150 ml of tetrahydrofuran was refluxed for 8 hours. The solvent was removed in vacuo, and 2N sodium hydroxide was added to the residue. The product was extracted with methylene chloride, and the extract was dried (sodium sulfate) and concentrated. The salt was precipitated with ethereal hydrochloric acid to give 13.8 g (56% of theory) of 1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride as a white crystalline solid.

المصدر