تفاعل #3872

معادلة التفاعل

potassium hydroxide

7-hydroxy-3-piperidino-2,2-dimethylbenzofuran

1,4-dibromobutane

→

desired product

7-(4-Bromobutoxy)-3-piperidino-2,2-dimethylbenzofuran

المذيبات

ether

ether

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   استخلاصextracted with 5% aq. HCl
3. 3
   غسيلthe acidic phase washed with ether
4. 4
   أخرىThe acidic phase is made basic thereby forming an oil which
5. 5
   غسيلwashed with sat'd aq. NaCl
6. 6
   أخرىdried
7. 7
   ترشيحfiltered
8. 8
   أخرىevaporated in vacuo

الإجراء التجريبي

Crushed potassium hydroxide (19.6 g) and tetrabutyl ammonium chloride (1.7 g) are added to a solution of 7-hydroxy-3-piperidino-2,2-dimethylbenzofuran (14.4 g) in 1,4-dibromobutane (69.4 ml) and the mixture stirred at RT under nitrogen for 5 hours. The reaction mixture is diluted with ether, washed with water, extracted with 5% aq. HCl and the acidic phase washed with ether. The acidic phase is made basic thereby forming an oil which is taken up in ether, washed with sat'd aq. NaCl, dried, filtered and evaporated in vacuo affording the desired product as a liquid.

المصدر