تفاعل #3871

معادلة التفاعل

1,3-dibromopropane

Potassium hydroxide

H2O

product

7-Hydroxy-3-piperidino-2,2-dimethylbenzofuran

→

desired product

7-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

المذيبات

diethyl ether

ether

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 5% aq. HCl
2. 2
   غسيلThe acidic solution is washed with ether
3. 3
   أخرىbasified, affording an oil which
4. 4
   غسيلwashed with sat'd NaCl
5. 5
   أخرىdried
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated in vacuo

الإجراء التجريبي

Potassium hydroxide (1.47 g), tetrabutyl ammonium chloride (0.77 g) and H2O (1 ml) are added to a solution of the product obtained in Step 6. (6.6 g) in 1,3-dibromopropane (27 ml). The reaction mixture is stirred for 20 hours and diluted with diethyl ether and washed with 5% aq. HCl. The acidic solution is washed with ether and basified, affording an oil which is taken up in ether, washed with sat'd NaCl, dried, filtered and evaporated in vacuo affording the desired product as an oil.

المصدر