تفاعل #3845

معادلة التفاعل

N-methyl-N-(2,3-dichlorophenyl)-2-pyridinesulfonamide

peracetic acid

→

N-methyl-N-(2,3-dichlorophenyl)-2-pyridinesulfonamide 1-oxide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe excess peracetic acid is removed under vacuum
2. 2
   workup.ADDITIONthe residue is diluted with methylene chloride
3. 3
   workup.ADDITIONpoured into water
4. 4
   غسيلwashed with brine
5. 5
   أخرىdried
6. 6
   أخرىevaporated to dryness
7. 7
   أخرىto give
8. 8
   أخرىafter purification

الإجراء التجريبي

N-methyl-N-(2,3-dichlorophenyl)-2-pyridinesulfonamide (1.7 g, 5.3 mmol) is treated with 40% peracetic acid (approx. 12 ml) at 35°-45° under N2 for 14 hours. The excess peracetic acid is removed under vacuum, and the residue is diluted with methylene chloride, poured into water, neutralized with aq. sodium bicarbonate, washed with brine, dried and evaporated to dryness to give, after purification, the title compound (compound 1, Table A).

المصدر