تفاعل #3841

معادلة التفاعل

3-methyl-2-(3-oxo-3H-benzo[d]isothiazol-2-yl)pentanoic acid

N-acetyl-L-cysteine

→

title compound

2-[2-(2-Acetylamino-2-carboxyethyldisulfanyl) benzoylamino]-3-methyl-pentanoic acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo
2. 2
   أخرىthe residue was triturated with 100 mL of 60° C. water
3. 3
   أخرىThe water was decanted
4. 4
   workup.DISSOLUTIONthe solid was dissolved in 50 mL of ethyl acetate
5. 5
   تجفيفThe organic solution was dried (MgSO4)
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated in vacuo

الإجراء التجريبي

A solution of 0.58 g (2.2 mmol) of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]isothiazol-2-yl)pentanoic acid in 20 mL of methanol was treated with 0.36 g (2.2 mmol) of N-acetyl-L-cysteine and the reaction was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was triturated with 100 mL of 60° C. water. The water was decanted and the solid was dissolved in 50 mL of ethyl acetate. The organic solution was dried (MgSO4), filtered and evaporated in vacuo to give the title compound as a white, solid foam, mp 85°-90° C.

المصدر