تفاعل #368138

معادلة التفاعل

tert-butyl 3(S)-[9-tert-butoxycarbonylamino-1(S)-ethoxycarbonylnonyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

hydrogen chloride-ethyl acetate

→

3(S)-[9-amino-1(S)-ethoxycarbonylnonyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride

المذيبات

ظروف التفاعل

المعالجة

1. 1
   أخرىis collected
2. 2
   أخرىdried under reduced pressure

الإجراء التجريبي

A mixture of tert-butyl 3(S)-[9-tert-butoxycarbonylamino-1(S)-ethoxycarbonylnonyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.33 g) and 5N hydrogen chloride-ethyl acetate solution (8 ml) is allowed to stand for 2.5 hours at room temperature. The mixture is diluted with petroleum ether (80 ml) to deposit colorless powder, which is collected and dried under reduced pressure to give 3(S)-[9-amino-1(S)-ethoxycarbonylnonyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride (0.25 g).

المصدر