تفاعل #367973

ord-cecb99b327504db0b8c305aa4a0e95ea

معادلة التفاعل

C[C@H](NP(=O)(Cc1ccccc1)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
Dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline
O
water
[Ca+2].[O-2]
calcium oxide
→
C[C@H](NP(=O)(Cc1ccccc1)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[O-].C[C@H](NP(=O)(Cc1ccccc1)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[O-].[Ca+2]
dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline calcium salt
المردود 83.8%

المتفاعلات

C[C@H](NP(=O)(Cc1ccccc1)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
Dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline
O
water
[Ca+2].[O-2]
calcium oxide

الكواشف

لا شيء

المذيبات

CCOC(C)=O
ethyl acetate

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    workup.ADDITIONwas added
  2. 2
    أخرىExcess of calcium oxide was removed by filtration
  3. 3
    workup.DISTILLATIONfrom the filtrate the solvent was distilled off under reduced pressure
  4. 4
    workup.ADDITIONn-hexane was added
  5. 5
    workup.STIRRINGwhile stirring

الإجراء التجريبي

Dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline (0.5 g, 0.9 mmole) was dissolved in ethyl acetate (15 ml) which had been previously saturated with water, and calcium oxide (50, 0.9 mmol) was added thereto. The mixture was stirred for 2 hours at room temperature. Excess of calcium oxide was removed by filtration, and from the filtrate the solvent was distilled off under reduced pressure. The thus obtained residue was dissovled in ethyl acetate, and n-hexane was added thereto while stirring to obtain dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline calcium salt (0.40 g).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04590178uspto-grants-1986_05