تفاعل #3678

معادلة التفاعل

NaOH

10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

triethylamine

diphenylphosphinyl chloride

→

white solid

المردود 96.4%

10-[4-[(Diphenylphosphinyl)amino]benzoyl]-10,11-dihydro-5H-pyrrolo-[2,1-c][1,4]benzodiazepine

المردود 96.4%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture is extracted with ethyl acetate
2. 2
   غسيلthe extract washed with brine
3. 3
   تجفيفdried (Na2SO4)
4. 4
   أخرىThe solvent is removed
5. 5
   أخرىthe residue triturated with ether-hexane

الإجراء التجريبي

A mixture of 0.10 g of 10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine 0.060 g of triethylamine and 0.12 g of diphenylphosphinyl chloride in 2 ml of dichloromethane is stirred at room temperature for 2 hours and then 1N NaOH is added. The mixture is extracted with ethyl acetate and the extract washed with brine and dried (Na2SO4). The solvent is removed and the residue triturated with ether-hexane to give 0.16 g of a white solid.

المصدر