تفاعل #367666

معادلة التفاعل

6-methoxynaphthoic acid

potassium carbonate

dimethyl sulfate

→

methyl 6-methoxynaphthoate

المردود 90.9%

المذيبات

acetone

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated to 50°-55° C. for 15 minutes
2. 2
   أخرىwere then slowly dripped in over a period of 15 minutes
3. 3
   درجة الحرارةThe mixture was then heated
4. 4
   درجة الحرارةat reflux for one hour

الإجراء التجريبي

A mixture of 9.1 g of 6-methoxynaphthoic acid and 7.2 g of anhydrous potassium carbonate in 45 ml of acetone was heated to 50°-55° C. for 15 minutes, and 4.5 ml of dimethyl sulfate were then slowly dripped in over a period of 15 minutes. The mixture was then heated at reflux for one hour and cooled to room temperature, after which all the acetone was stripped under vacuum. After workup, it was determined that the process resulted in the formation of 8.85 g of methyl 6-methoxynaphthoate having an HPLC purity of 83.3%.

المصدر