تفاعل #366938

معادلة التفاعل

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

المردود 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

المردود 92.8%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىthe volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   درجة الحرارةchilled
4. 4
   ترشيحfiltered
5. 5
   أخرىdried

الإجراء التجريبي

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

المصدر