تفاعل #366792

معادلة التفاعل

Oxalyl chloride

2-chloro-6-methyl-pyridine-4-carboxylic acid

→

methyl 2-chloro-6-methyl-pyridine-4-carboxylate

المردود 100.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىThe volatiles were removed by evaporation and methanol (20 ml)
2. 2
   workup.ADDITIONadded to the residue
3. 3
   workup.STIRRINGThe mixture was stirred for 1 hour
4. 4
   أخرىthe volatiles removed by evaporation

الإجراء التجريبي

Oxalyl chloride (1.9 g, 15 mmol) was added to 2-chloro-6-methyl-pyridine-4-carboxylic acid (1.7 g, 10 mmol) in methylene chloride (30 ml) and the mixture stirred for 2 hours. The volatiles were removed by evaporation and methanol (20 ml) added to the residue. The mixture was stirred for 1 hour and the volatiles removed by evaporation to give methyl 2-chloro-6-methyl-pyridine-4-carboxylate (1.85 g, 100%) as an off-white solid.

المصدر