تفاعل #365747

معادلة التفاعل

ethyl 4-bromobenzoate

4-pyridyl borate

sodium hydrogen carbonate

1,2-dimethoxyethane

→

title compound

المردود 56.3%

Ethyl 4-(4-pyridyl)benzoate

المردود 56.3%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith reflux under nitrogen atmosphere
2. 2
   استخلاصthe solution was extracted with ethyl acetate
3. 3
   غسيلThe extract was washed with water
4. 4
   تجفيفdried (MgSO4)
5. 5
   تركيزconcentrated
6. 6
   غسيلeluted with hexane-ethyl acetate (2:1)

الإجراء التجريبي

To a mixture of ethyl 4-bromobenzoate (2.29 g), 4-pyridyl borate (1.23 g), 1 M sodium hydrogen carbonate solution (30 ml) and 1,2-dimethoxyethane (40 ml) was added tetrakis(triphenylphosphine)palladium (0.3 g) and the mixture was stirred for 3 hours with reflux under nitrogen atmosphere. To the mixture was added water and the solution was extracted with ethyl acetate. The extract was washed with water, dried (MgSO4) and concentrated. The residue was subjected to silica gel chromatography, and eluted with hexane-ethyl acetate (2:1) to give the title compound as crystals (1.15 g, 50.7%).

المصدر