تفاعل #365480

معادلة التفاعل

(4-pent-2-ynyloxy-benzenesulfonyl)-acetic acid ethyl ester

(4-bromo-benzyl)-bis-(2-chloro-ethyl)-amine

→

1-(4-Bromo-benzyl)-4-(4-pent-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

ظروف التفاعل

المعالجة

1. 1
   أخرىwas isolated

الإجراء التجريبي

1-(4-Bromo-benzyl)-4-(4-pent-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method as outlined in Example 1 (Step 6). Starting from (4-pent-2-ynyloxy-benzenesulfonyl)-acetic acid ethyl ester (4 g, 12.9 mmol) and (4-bromo-benzyl)-bis-(2-chloro-ethyl)-amine (5.83 g, 16.8 mmol, 2.85 g of the product was isolated. Yield 2.85 g (31%); low melting white solid; MS: 549.9 (M+H)+

المصدر