تفاعل #364948

معادلة التفاعل

diisopropylethyl amine

1-(4′-cyanobenzyl)-5-chloromethylimidazole

acetonitrile

1-benzyl 1-piperazine carboxylate

→

1-(4′-Cyanobenzyl)imidazol-5-ylmethyl Piperazine-4-carboxylic Acid Benzyl Ester

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was isolated
2. 2
   أخرىafter silica column purification

الإجراء التجريبي

To an acetonitrile solution of 1-(4′-cyanobenzyl)-5-chloromethylimidazole (7.45 mmol), prepared as described in Example 1, Step 4, and diisopropylethyl amine (22.4 mmol) was added 1-benzyl 1-piperazine carboxylate (10.4 mmol). This solution was stirred for 4.0 hours at 80° C. The product was isolated after silica column purification.

المصدر