تفاعل #364068

معادلة التفاعل

1-t-Butoxycarbonyl-4-hydroxy-4-(2-methoxyphenyl)piperidine

trifluoroacetic acid

→

aforementioned compound

المردود 69.1%

1-t-Butoxycarbonyl-4-(2-methoxyphenyl)-1,2,3,6-tetrahydropyridine

المردود 69.1%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction solution was washed with saturated sodium bicarbonate aqueous solution and saturated brine in that order
2. 2
   تجفيفdried with anhydrous sodium sulfate
3. 3
   أخرىThen the compound obtained by the evaporation of the solvent under a reduced pressure
4. 4
   أخرىwas separated
5. 5
   أخرىpurified by a silica gel column chromatography
6. 6
   أخرىto obtain

الإجراء التجريبي

1-t-Butoxycarbonyl-4-hydroxy-4-(2-methoxyphenyl)piperidine (230 mg, 0.75 mmol) was dissolved in methylene chloride (10 ml). Thereto was added trifluoroacetic acid (0.20 ml, 2.6 mmol) and the resulting solution was stirred at a room temperature for 2.5 hours. The reaction solution was washed with saturated sodium bicarbonate aqueous solution and saturated brine in that order and dried with anhydrous sodium sulfate. Then the compound obtained by the evaporation of the solvent under a reduced pressure was separated and purified by a silica gel column chromatography to obtain 150 mg of the aforementioned compound of interest (0.53 mmol, 71% in yield).

المصدر