تفاعل #363655

معادلة التفاعل

(1S)-1-(Hydroxymethyl)-3-methylbutylamine

2-hydroxyethylamine

2-hydroxyethylamine

(2S)-4-methyl-2-(isobutylamino)pentan-1-ol

N-(isobutyl)ammonium chloride

(L)-leucine methyl ester

4-Cyanophenyl isothiocyanate

N-(isobutyl)ammonium chloride

→

(4S)-2-(4-cyanophenylimino)-3,4-diisobutyl-1,3-thiazolidine

ظروف التفاعل

الإجراء التجريبي

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (2S)-4-methyl-2-(isobutylamino)pentan-1-ol as described in Method B4c. The resulting 2-hydroxyethylamine was converted to N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride according to Method B7c. 4-Cyanophenyl isothiocyanate was reacted with N-(1S)-1-(chloromethyl)-3methylbutyl)N-(isobutyl)ammonium chloride to Method C1f to afford (4S)-2-(4-cyanophenylimino)-3,4-diisobutyl-1,3-thiazolidine.

المصدر