تفاعل #363652

معادلة التفاعل

4-nitro-1-naphthyl isothiocyanate

(1S)-1-(Hydroxymethyl)-3-methylbutylamine

(L)-leucine methyl ester

4-Nitro-1-naphthyl isothiocyanate

(1S)-1-(hydroxymethyl)-3-methylbutylamine

4-Nitro-1-naphthylamine

→

(4S)-2-(4-nitro-1-naphthylimino)-4-isobutyl-1,3-thiazolidine

ظروف التفاعل

الإجراء التجريبي

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. 4-Nitro-1-naphthylamine was converted to 4-nitro-1-naphthyl isothiocyanate according to Method A2b. 4-Nitro-1-naphthyl isothiocyanate was reacted with (1S)-1-(hydroxymethyl)-3-methylbutylamine to Method C2a to give (4S)-2-(4-nitro-1-naphthylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-nitro-1-naphthylimino)-3,4-diisobutyl-1,3-thiazolidine.

المصدر