تفاعل #363614

معادلة التفاعل

(1S)-1-(Hydroxymethyl)-3-methylbutylamine

2-hydroxyethylamine

(2S)-4-methyl-2-(isobutylamino)pentanol

N-(isobutyl)ammonium chloride

(L)-leucine methyl ester

4-Nitrophenyl isothiocyanate

N-(isobutyl)ammonium chloride

→

2-(4-nitrophenylimino)-3,5-diisobutyl-1,3-thiazolidine

ظروف التفاعل

الإجراء التجريبي

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (2S)-4-methyl-2-(isobutylamino)pentanol as described in Method B4c, Steps 1-2. The alcohol was converted to N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride as described in Method B7c. 4-Nitrophenyl isothiocyanate was reacted with N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride according to Method C1f to give 2-(4-nitrophenylimino)-3,5-diisobutyl-1,3-thiazolidine.

المصدر