تفاعل #362840
ord-b0d1e0b5359340c1aa863386b79bc1a2
معادلة التفاعل
sodium trimethylsilanolate
sodium trimethylsilanolate
ethyl N-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)carbamate
DBU
DBU
sodium hydride
ethyl 3-amino4,4,4-trifluorocrotonate
→
title compound
3-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)-6-trifluoromethyl-2,4-(1H,3H)-pyrimidinedione
المتفاعلات
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىThis compound was prepared
الإجراء التجريبي
This compound was prepared using 4.0 grams (0.036 mole) of sodium trimethylsilanolate, 6.6 grams (0.036 mole) of ethyl 3-amino4,4,4-trifluorocrotonate, 8.5 grams (0.032 mole) of ethyl N-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)carbamate, and 2.2 grams (0.014 mole) of DBU in 75 mL of DMF. This preparation differs from well-known literature preparations for pyrimidinedione rings in that sodium trimethylsilanolate and DBU were used rather than sodium hydride. The yield of title compound was 1.7 grams. The NMR spectrum was consistent with the proposed structure.