تفاعل #362639

معادلة التفاعل

6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

bromomethyl methyl ether

acetic acid

→

6-methoxymethoxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONthe solution is poured onto ice
2. 2
   استخلاصextracted with methylene chloride
3. 3
   غسيلThe organic phase is washed with water
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   أخرىthe title product is purified
6. 6
   غسيلeluting with methylene chloride

الإجراء التجريبي

50 grams (0.2 mol) of 6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid are dissolved in 150 cm3 of anhydrous pyridine. 16.34 cm3 (0.2 mol) of bromomethyl methyl ether are added dropwise. The mixture is stirred for 2 hours and then the solution is poured onto ice. The mixture is acidified with acetic acid and then extracted with methylene chloride. The organic phase is washed with water and dried over anhydrous sodium sulfate, then the title product is purified by passing through a column of silica gel, eluting with methylene chloride.

المصدر