تفاعل #361901

معادلة التفاعل

4-[3-(2-aminobenzoylamino)propylthio]pyridine

1,1'-carbonyldiimidazole

→

desired product

المردود 65.7%

3-[3-(4-pyridylthio)propyl]-quinazoline-2,4(1H,3H)-dione

المردود 65.7%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   غسيلThe solution was washed with water
4. 4
   أخرىdried
5. 5
   workup.DISTILLATIONThe solvent was distilled off
6. 6
   أخرىthe residue was recrystallized from ethanol/chloroform/ether

الإجراء التجريبي

Under nitrogen atmosphere, to a solution of 718 mg (2.5 mmol) of 4-[3-(2-aminobenzoylamino)propylthio]pyridine in 15 ml of tetrahydrofuran, 811 mg (5.0 mmol) of 1,1'-carbonyldiimidazole was added, and the mixture was stirred at room temperature for 16 hours. The solvent was distilled off and the residue was dissolved in chloroform. The solution was washed with water and dried. The solvent was distilled off and the residue was recrystallized from ethanol/chloroform/ether to give 514 mg of the desired product (65.7% yield, white crystals).

المصدر