تفاعل #361554

معادلة التفاعل

4-Amino-1-phenylmethyl-1H-imidazo[4,5-c]quinoline-2-methanol

thionyl chloride

→

2-Chloromethyl-1-phenylmethyl-1H-imidazo[4,5-c]quinolin-4-amine Hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرىhad crystallized from solution
2. 2
   workup.ADDITIONThe mixture was diluted with dry ether (75 mL)
3. 3
   ترشيحThe solid was filtered from the mixture
4. 4
   غسيلwashed with ether
5. 5
   أخرىthoroughly dried
6. 6
   أخرىsuch without further characterization or purification

الإجراء التجريبي

4-Amino-1-phenylmethyl-1H-imidazo[4,5-c]quinoline-2-methanol (2.0 g; 0.0066 mol, Example 27) was added in small portions to thionyl chloride (10 mL). After stirring at room temperature for 30 min the product had crystallized from solution. The mixture was diluted with dry ether (75 mL). The solid was filtered from the mixture, washed with ether, and thoroughly dried. The product was used as such without further characterization or purification.

المصدر