تفاعل #361127

معادلة التفاعل

2-undecanone

glyoxylic acid monohydrate

phosphoric acid

→

4-ketotridec-2-enoic acid

المذيبات

ethyl ether dichloromethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas warmed at 80° for 18 hours
2. 2
   غسيلwashed thoroughly with brine
3. 3
   أخرىEvaporation of the
4. 4
   تجفيفdried (magnesium sulphate) organic phase
5. 5
   أخرىgave a yellow oil which
6. 6
   أخرىon crystallization from ethyl ether/petroleum ether

الإجراء التجريبي

A mixture of 2-undecanone (10 g, 58.7 mmol), glyoxylic acid monohydrate (5.15 g, 56 mmol) and 85% phosphoric acid (10 ml) was warmed at 80° for 18 hours. On cooling to room temperature, the mixture was diluted with ethyl ether/dichloromethane (50 ml each) and washed thoroughly with brine. Evaporation of the dried (magnesium sulphate) organic phase gave a yellow oil which on crystallization from ethyl ether/petroleum ether gave 4-ketotridec-2-enoic acid as colorless prisms.

المصدر