تفاعل #3593

معادلة التفاعل

4-[(2-methylbenzoyl)amino]benzoic acid

thionyl chloride

→

desired product

4-[(2-Methylbenzoyl)amino]benzoyl chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 1.5 hours
2. 2
   تركيزThe solution is concentrated in vacuo
3. 3
   workup.ADDITIONToluene is added
4. 4
   أخرىthe solvent removed in vacuo
5. 5
   workup.ADDITIONToluene is added
6. 6
   درجة الحرارةthe mixture chilled
7. 7
   ترشيحfiltered

الإجراء التجريبي

A mixture of 10.3 g of 4-[(2-methylbenzoyl)amino]benzoic acid and 32 ml of thionyl chloride is refluxed for 1.5 hours. The solution is concentrated in vacuo. Toluene is added and the solvent removed in vacuo. Toluene is added and the mixture chilled and filtered to give the desired product as a yellow solid, 135°-141° C.

المصدر