تفاعل #358827

معادلة التفاعل

K2CO3

N-(2-chloroethyl)-pyrrolidine-hydrochloride

4-bromo-2-chloro-phenol

→

1-[2-(4-bromo-2-chloro-phenoxy)-ethyl]-pyrrolidine

المذيبات

DMF

EtOAc

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted once with 30 mL water and twice with 30 mL
2. 2
   تجفيفThe organic phase is dried over MgSO4
3. 3
   أخرىFurther purification

الإجراء التجريبي

415 mg (3.00 mmol) K2CO3 and 170 mg (1.00 mmol) N-(2-chloroethyl)-pyrrolidine-hydrochloride is added to a solution of 207 mg (1.00 mmol) 4-bromo-2-chloro-phenol in 5 mL DMF and the mixture is stirred for 24 h at RT. The reaction mixture is diluted with 50 mL EtOAc, extracted once with 30 mL water and twice with 30 mL semisaturated NaHCO3 solution. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. Further purification is carried out by column chromatography on silica gel (gradient: DCM to DCM/MeOH 9:1).

المصدر