تفاعل #358505

معادلة التفاعل

2,6-dichloro-4-cyanobenzoic acid methylester

azidotributyltin

→

title compound

2,6-dichloro-4-tetrazolylbenzoic Acid Methylester

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   ترشيحAfter Celite filtration
4. 4
   تركيزthe filtrate was concentrated
5. 5
   أخرىthe residue was purified by reverse phase HPLC

الإجراء التجريبي

The mixture of 185 mg of 2,6-dichloro-4-cyanobenzoic acid methylester, 266 mg of azidotributyltin and 5 ml of toluene was stirred at 100° C. for 3 days. The reaction mixture was concentrated and diluted with ethyl acetate. After Celite filtration, the filtrate was concentrated and the residue was purified by reverse phase HPLC to obtain the title compound.

المصدر