تفاعل #357288

معادلة التفاعل

(2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate

methyl 2-hydroxy-4-methylbenzoate

Cs2CO3

→

subtitled compound

Methyl 4-methyl-2-[(2S)-oxiran-2-ylmethoxy]benzoate

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was partitioned between ethyl acetate and H2O
2. 2
   تجفيفThe organic layer was dried over Na2SO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by silica gel flash chromatography (0-20% ethyl acetate in petroleum spirit)

الإجراء التجريبي

A mixture of (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (777.7 mg, 3.0 mmol), methyl 2-hydroxy-4-methylbenzoate ((498.5 mg, 3.0 mmol) and Cs2CO3 (1.17 g, 3.6 mmol) in DMF (10 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-20% ethyl acetate in petroleum spirit) to give the subtitled compound (500 mg).

المصدر